Establishment of a Novel R&D Center for Bio-devices Based on Bio-chips

Examples of applications of such bio devices can include: environmental diagnostic sensors, smart implants for humans or animals intended for treatment and/or diagnostics, lab on a chip etc.

The center(s) can include equipment such as chip manufacturing infrastructure, software tools, analysis equipment, wet labs, bioprinting infrastructure etc. which will enable research, development, and planning services, prototyping, validation, and more of the Bio-devices.

Following the above, among the objectives of this Call for proposals are:

1. Providing R&D services by a team of expert personnel, helping and accelerating the development process. Thus, saving time and money, for the industrial corporations which develop BD based on BCP. The above team can operate with their internal unique equipment and knowledge and/or combined with the capabilities of strategic collaborations with other entities from Israel or globally, that complement the applicant’s capabilities.
2. Providing production capabilities for prototypes and small series based on the applicant’s infrastructure (equipment, etc.) and/or based on creating strategic collaborations with other entities from Israel or globally, that complement the applicant’s capabilities.
3. Developing unique knowledge and providing solutions, which in its turn, will enable industrial corporations, research institutions, or other entities to be international leaders in their domain.
4. Carrying out training and human capital development for providing R&D services to industrial corporations and research institutes.

Below are examples for R&D services that will be provided by the center:

1. Research, development and designing – such as research, development, consulting, design of the electronic elements of the bio-chip, design of the electronic-biologic interface, design of diagnostic and monitoring devices for biological processes, designs of labs-on-a-chip.As described above there are various applications of the developed products such as drug development processes, environmental sensors (for example to monitor bacteria or gases), monitoring processes in the human body or animals, diagnostic and treatment of the human body (for example controlled and targeted release of drugs and/or while measuring the effect of the medical therapy).

   Examples of personnel/equipment that will enable the above:

   • Experts in the fields of hardware, software, materials, data, biology, chemistry, and hardware-biology/chemistry/materials interfaces.
   • Software for planning and simulation tools of the BD based on BCP components on their various aspects.
2. Prototype production – for example, production of bio-chips based on semiconductor technologies which will be used as a component of the bio device; production of components of the bio device system such as microfluidic devices; production of optical components or production of biological components of the bio-chip. The production technologies selected for the process should be those which will allow repeatability and the production of large-scale series in the mass production phase.Examples of personnel/equipment which will enable the above:
   • Experts in various fields of engineering and experts to operate the equipment and processes.
   • Clean rooms, 3D printers, and biological printing (using various materials including biomaterials), equipment for mechanical work, chemical laboratory, biological laboratory, imaging equipment, and electronic testing equipment.
3. Verification and validation – for example: performing tests required to examine the performance of the product in various relevant aspects (mechanical tests, shelf life, environmental etc.). This step will allow the product to be pre-evaluated and adjusted to meet regulatory standards.An example of personnel/equipment which will enable the above:
   • Experts in planning testing methods and processes, experts in quality assurance in various fields.
   • Laboratories and test equipment suitable for various technological fields (hardware, chemistry, biology, mechanics, etc.).
4. Collaborative laboratories or dedicated laboratories – A laboratory containing valuable equipment that would allow examination of various aspects of the product’s functionality, integration of components, unique analysis of the components produced (for example, the composition of materials, biological activity). Or can expand its equipment and services following the requirements of a specific customer.An example of personnel/equipment that will enable the provision of the above:
   • Potential space for physical expansion of the infrastructure

In an overall view of the infrastructure and services providing, the infrastructure can also include a CEO and dedicated Business Development manager.

Funding