{"id":4015,"date":"2023-06-25T12:45:44","date_gmt":"2023-06-25T12:45:44","guid":{"rendered":"https:\/\/innovationisrael.org.il\/en\/?post_type=report&p=3258"},"modified":"2023-08-15T10:21:53","modified_gmt":"2023-08-15T10:21:53","slug":"would-you-care-for-a-bite-of-the-future","status":"publish","type":"article","link":"https:\/\/innovationisrael.org.il\/en\/article\/would-you-care-for-a-bite-of-the-future\/","title":{"rendered":"Would You Care for a Bite of the Future?"},"content":{"rendered":"\n
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The warning sign issued by scientists and professionals is clear \u2013 the growth of the world’s population and its dwindling resources mean that, in the future, it will no longer be possible to produce enough meat to feed everyone. No-one engaged in this field has any doubt of the urgent need to find an immediate solution for this problem. <\/p>\n\n\n\n
This is the background to the meteoric development of meat substitutes and cultivated meat industries. The two are not the same \u2013 meat substitutes are based on plant protein or protein resulting from fermentation, while cultivated meat, in contrast, is real meat. Cells are taken from a live cow and grown in a bioreactor with plant material while providing them with an environment that simulates growing in a real cow. The result is a genuine piece of meat.<\/p>\n\n\n\n
The advantages are tremendous: first, the end-product is not a substitute for meat but rather, identical in taste and composition to the real thing. The difference is that this meat is produced without harming animals, while using significantly less energy, and with a fraction of the water needed to grow a cow. <\/p>\n\n\n\n
So, what’s the problem? Dr. Dana Yarden and Dr. Amit Yaari, from the Israeli startup BioBetter, explain that growing cattle, fish, or poultry cells in a bioreactor requires what are known as ‘growth factors’ \u2013 proteins with which it is possible to control the division or differentiation of the cells. Unlike bacteria that don’t need more than water and sugar to thrive, cells of complex beings need signals, and these are the growth factors. Without growth factors, it is simply impossible to grow cells. <\/p>\n\n\n\n
The problem is that growth factors are extremely expensive, and this, in turn, raises the cost of producing cultivated meat to more than 300 dollars per kilo. In practice, 55%-65% of the cost of producing cultivated meat is derived from the cost of the growth factors. The cost is so high that it raises a question mark over the feasibility of the entire cultivated meat technology. Without a solution to this problem, cultivated meat cannot be produced at reasonable and affordable prices. <\/p>\n\n\n\n
A further problem is production capacity. For example, the total production capacity of the global insulin industry in a year is around 17 thousand tons and is used primarily for pharmaceutical applications. This capacity will allow to address only 10% of the cultivated meat industry requirement, not to mention the entire predicted scope of cellular agriculture. <\/p>\n\n\n\n
This is where BioBetter enters the picture. The company was established by Prof. Oded Shoseyov from the Hebrew University, Dr. Dana Yarden, and Avi Tzur \u2013 an industrialist who lives in Brazil where he worked in the field of tobacco and was the company’s first investor. They were joined a short time later by the company’s CEO Dr. Amit Yaari who completed his doctorate on collagen produced from tobacco plants in Prof. Shoseyov’s laboratory. BioBetter, that started out in the Innovation Authority’s Katzrin incubator, and which focused on manufacturing pharmaceuticals, made the transition to the field of food-tech following the Covid pandemic. <\/p>\n\n\n\n
The company operates from Kiryat Shmona and contributes to the city’s standing as a food-tech stronghold. “Kiryat Shmona became the food-tech capital of Israel as the result of efforts by Erel Margalit’s JVP Fund (that recently invested 10 million dollars \u2013 the largest ever investment in a startup based in Kiryat Shmona) and the opening of the Fresh Start food-tech incubator, and we understood that we had the capability of producing a critical component of the cultivated meat industry. Everything came together nicely with agriculture in the northern region of Israel. This is very significant in the field’s development and that of other startups in the region. <\/p>\n\n\n\n
“We enjoyed the support of the Innovation Authority the whole way \u2013 during the initial years of operation in the Katzrin incubator, and also over the past two years with the transition to activity in the field of cultivated meat. The Authority makes great effort to advance food-tech R&D and has also recently supported the cultivated meat consortium program that provides impetus to both new and existing companies to enter this important and interesting field. The Authority is clearly investing extensive thought and effort to develop the field of biotechnology in Israel”.<\/p>\n\n\n\n
BioBetter’s solution is based on an understanding of the need for ‘disruptive technology’ \u2013 technology that completely alters the industry’s existing technology and offers a solution: in our case, the use of plants as bioreactors.<\/p>\n\n\n\n
One of the reasons for the growth factors’ high cost is their complex structure which not all cell types can produce. Bacteria or yeast cannot efficiently produce growth factors and need numerous and inefficient stages of production which raise the cost. BioBetter uses tobacco plants that can also correctly and efficiently produce complex human proteins such as collagen, antibodies and other proteins. The company inserts the genetic sequence that causes the production of growth factors into the plant’s genome, thereby enabling to plant a seed in a field that grew naturally, creates the protein, and preserves sterility and suitable conditions within the cell \u2013 until the harvest. <\/p>\n\n\n\n
As BioBetter’s CEO, Dr. Yaari explains: “one extremely significant advantage of molecular farming (the production of proteins in plants that grow in open fields) is that everything exists already. Tobacco farmers have equipment, fields, and experience and there is no need for significant capital investment (Capex). Furthermore, when adopting a longer-term view, many tobacco farmers have become unemployed due to the decline in tobacco consumption. Yet another advantage is that the operational costs are dramatically lower compared to other solutions because there is no need for amino-acids, sugars, heating, expensive human labor etc.”.<\/p>\n\n\n\n
BioBetter has developed a unique and patent-protected purification technology that cleans the growth factors of the plant proteins and disposes of the nicotine and proteins in a quick, efficient, and cheap manner that is suitable for very large-scale operations. At the end of the cleaning process, the quantities of remnant tobacco impurities in the cultivated meat are negligible.<\/p>\n\n\n\n
“Our solution is extremely environment-friendly”, explains co-founder Dr. Yarden. “We make use of plants that only consume air, water and light and can therefore achieve very large-scale results, with the only limitation being the area of land at our disposal. <\/p>\n\n\n\n
BioBetter initially produced the growth factors and cleaned them and were the first in Israel to develop a long line of cell tests. “We started to give samples for testing to local and international meat companies and, according to them, our development works well compared to the existing commercial material on the market. We are now striving to finalize commercial contracts with these companies”, says Dr. Yaari. BioBetter’s solution currently integrates with the market because there are still no companies producing and selling cultivated meat on a large scale. The entire industry is concentrated in the northern region, in a small biotechnology company in Kiryat Shmona. Over the next two years, they plan to increase growing capacity to several dunams and to produce hundreds of grams of growth factors a year.<\/p>\n\n\n\n
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